Hemoglobin I: an inherited hemoglobin anomaly.
نویسندگان
چکیده
By D. L. RUCKNAGEL, E. B. PAGE AND W. N. JENSEN S TUDIES OF HEMOGLOBIN by the various technics of electrophoresis aud alkali denaturatiomi have resulted imi a strikimig development in the knowledge of abnormal hemoglobins amid in the hereditary hemolytic amieniias, some of them never previously recognized. During the course of the examination of the electrophoretic properties of the hemoglobimis of Negro patients admitted to the medical service of the hospital, a previously undescribed abnormal hemoglobimi characterized by a rapid electrophoretic mobility at pH 8.6 was detected.’ The abmiormal hemoglohins already described include types S, C, D, E, G, amid H. It. is proposed that. this seventh abnormal pigment he designated as hemoglobin J#{149}2
منابع مشابه
Hemoglobin I: An Inherited Hemoglobin Anomaly
By D. L. RUCKNAGEL, E. B. PAGE AND W. N. JENSEN S TUDIES OF HEMOGLOBIN by the various technics of electrophoresis aud alkali denaturatiomi have resulted imi a strikimig development in the knowledge of abnormal hemoglobins amid in the hereditary hemolytic amieniias, some of them never previously recognized. During the course of the examination of the electrophoretic properties of the hemoglobimi...
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I N 1955 RIGAS ET AL.1 and Gouttas et al.2 independently reported the discovery of a new hemoglobin characterized electrophoretically at pH 8.6 by a more rapid anodal mobility than that of normal adult hemoglobin. This hemoglobin has subsequently been identified by the letter “H.” More recently, “fast” hemoglobins other than “H” have been described. These include hemoglobins J,3 J,4-1#{176} K,5...
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Hemoglobinopathies are most common inherited disorders in the world; approximately 7 percent of the worldwide population and 5-6 percent of population of Iran are carriers. The hemoglobin disorders inherit as autosomal recessive and are very common in the Mediterranean area and much of the Asia and Africa. The control of this inherited disorders need to genetic counseling and accurate screening...
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H EREDITARY PERSISTENCE OF FETAL HEMOGLOBIN is a term tentatively applied to a specific inherited anomaly manifested throughout life by the presence of large amounts of fetal hemoglobin in the erythro-cytes in the absence of anemia or clinical manifestations. The abnormality is attributable to a single autosomal genetic factor. Since the primary effect of the mutant gene is unknown, designation...
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Abstract Background and Objectives Thalassemia is a group of inherited hemoglobin disorders with defect in the synthesis of hemoglobin chains. Case The young couple resident in Bandar Abbas, a 23 year old woman with MCV:63fl; MCH:19; HbA2:3.9 and a 25 year old man with MCV:94fl; MCH:32; HbA2:2.1; HbF:36, were referred to the Bandar Abbas Medical Genetic & PND Center for genetic counsell...
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ورودعنوان ژورنال:
- Blood
دوره 10 10 شماره
صفحات -
تاریخ انتشار 1955